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KMID : 0869220120160010031
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Journal of Korean Geriatric Psychiatry
2012 Volume.16 No. 1 p.31 ~ p.37
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Association between Depression and Education Level in Alzheimer’s Dementia : A CREDOS (Clinical Research Center for Dementia of South Korea) Study
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Song Ki-Hye
Myung Woo-Jae
Lee Yu-Jin
Kim Sang-Ha
Yoon Hye-Yeon
Choi Jun-Bae
Kang Hyo-Shin
Lim Shinn-Won
Na Duk-Lyul
Kim Seong-Yoon
Lee Jae-Hong
Han Seol-Heui
Choi Seong-Hye
Kim Sang-Yun
Kim Doh-Kwan
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Abstract
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Objectives：We aimed to identify the association depression with education level in patients with Alzheimer’s dementia (AD).
Methods： We examined 911 patients with AD in CREDOS (Clinical Research Center for Dementia of South Korea) study and designed cross-sectional study. Each patient underwent psychiatrical, neurological and medical examination, interview for caregivers, laboratory tests, neuropsychological tests, and brain MRI. Cognitive function was measured using Korean version of Mini-Mental State Examination, Global Deterioration Scale and Clinical Dementia Rating. Psycho-Behavioral symptom was measured using Caregiver-Administered Neuropsychiatric Inventory. Daily Living was measured using Barthel Index for daily living activities and Seoul-Instrumental Activities of Daily Living. Depressive symptoms using the Korean version of the Short form on Geriatric Depression Scale were measured. Education was classified into low, intermediate, and high levels. 621 patients were performed APOE genotyping among the 911 patients
Results： Out of the 911 patients, 477 were low education, 287 were intermediate education, and 147 were high education. 341 patients had depression. In logistic regression model we confirmed low education was the risk factor of depression (OR 2.26, 95% CI 1.66-3.07).
Conclusion：This study confirmed that low education was associated with depression in Alzheimer’s dementia.
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KEYWORD
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Alzheimer’s dementia, Depression, Education
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